一、中文名称：Research Grade Vatreptacogalfa (DHC35901)，凝血因子VIIa类似物

二、产品描述
AnrFVIIa类似物由诺和诺德公司研发，旨在为血友病患者及抑制剂患者提供一种安全、快速、可靠的急性出血解决方案。该产品针对减少再治疗需求、减轻静脉穿刺带来的疼痛、降低止血药物及镇痛药消耗，以及减少对日常活动的干扰，具有显著的临床益处。rFVIIa类似物（前称NN1731）的活性药物成分的国际非专利名称（INN）为vatreptacogalfa（激活型），并以此作为药物的命名。

三、产品详情
名称：Research Grade Vatreptacogalfa (DHC35901)
别名：rFVIIa analog, NN1731, FVIIa DVQ, Eptacog Alfa
货号：DHC35901
表达系统：哺乳动物细胞
种属反应性：人类
同种型：重组凝血因子VIIa (rFVIIa) 的三种氨基酸替代物（Asp158Val, Val296Glu, 和Glu298Met）
克隆类型：单克隆抗体
靶标：F7, Proconvertin, SPCA, 血清前凝血酶转换加速因子, 凝血因子VII, Eptacogalfa
浓度：1mg/ml
内毒素水平：请联系实验室获取相关信息
纯度：经SDS-PAGE鉴定为95%
纯化方式：由镍柱法纯化
Accession号：P08709
克隆号：Vatreptacogalfa
应用：研究级生物仿制品
状态：液体
保存溶液：0.01M PBS, pH 7.4
稳定性和存储：
- 短期存储（1-2周）：4°C
- 中期存储（12个月）：-20°C
- 长期存储：-80°C

四、参考文献：
1. Vatreptacogalfa from conception to clinical proof of concept. PMID: 22510860
2. Recombinant factor VIIa analog (vatreptacogalfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial. PMID: 22470921
3. Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacogalfa, are associated with clinical immunogenicity. PMID: 26362483
4. Recombinant factor VIIa analog in the management of hemophilia with inhibitors: results from a multicenter, randomized, controlled trial of vatreptacogalfa. PMID: 24931322
5. Overcoming delayed in-vitro response to FVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacogalfa) concentration escalation in whole blood assays. PMID: 21681082
6. The MHCAssociated Peptide Proteomics assay is a useful tool for the non-clinical assessment of immunogenicity. PMID: 37915568
7. Hemostatic properties of the FVIIa analog NN1731. PMID: 22446168
8. Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue. PMID: 31506285
9. Pharmacokinetics and pharmacodynamics of rFVIIa and new improved bypassing agents for the treatment of hemophilia. PMID: 22757678
10. Post-hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools. PMID: 28077675
11. The effect of acylation with fatty acids and other modifications on HLA class II: peptide binding and T cell stimulation for three model peptides. PMID: 29758051

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